Meta-analysis Finds Standardized St. John’s Wort Extracts as Effective as Conventional Antidepressants


Crooked Bear Creek Organic Herbs

  • St. John’s Wort (Hypericum perforatum, Hypericaceae)

St. John’s wort (SJW; Hypericum perforatum, Hypericaceae) aerial parts are a popular treatment for depression, and many countries in Europe prescribe SJW for that purpose. According to the authors, SJW has been well researched; however, the results are conflicting. The last large published meta-analysis was conducted in 2008, and it found SJW superior to placebo and similar to conventional antidepressants. Since then, additional research has emerged. Hence, the objective of this systematic review and meta-analysis was to provide an updated analysis.

The following databases were searched from January 1, 1960, through May 1, 2016, according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines: PubMed; Ovid; Clinical Trials Register of the Cochrane Collaboration Depression, Anxiety and Neurosis Group (CCDANTR); Cochrane Field for Complementary Medicine; China National Knowledge Infrastructure; and Wanfang. The following search terms were used: [St John’s…

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